New Nordic Renal Diet May Benefit Patients With Moderate CKD

The plant-based new Nordic renal diet may reduce renal excretion of phosphate, acids, and uremic toxins in patients with stage 3-4 chronic kidney disease, investigators report.

In a randomized crossover trial, 18 patients with an estimated glomerular filtration rate of 16-45 mL/min/1.73 m² received 7 days of a habitual Danish diet and 7 days of the new Nordic renal diet with a washout period in between.

The Nordic diet improved parameters of phosphate homeostasis over the short term, Louise Salomo, PhD, of University Hospital of Copenhagen in Rigshospitalet, Denmark, and colleagues reported in Nephrology Dialysis Transplantation. It significantly reduced 24-h urine phosphorus excretion by 313 mg/d. At baseline, the mean phosphorus level was 875 mg/d. The level decreased by 400 vs 87 mg/d during the Nordic renal diet and habitual diet periods, respectively. Compared with a typical Danish diet, the new Nordic renal diet significantly reduced 24-hour urine fractional excretion of phosphorus by 11% and FGF23 by 30 pg/mL.

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In a post hoc analysis, the investigators further found that the Nordic renal diet improved metabolic acidosis and reduced uremic toxins. By 7 days, it had significantly decreased 24-hour urine net acid excretion by 80% and 24-hour urine excretion of ammonium by 34%, compared with the control period, Nikita Misella Hansen, MSc, of University Hospital of Copenhagen in Denmark, and colleagues reported in the Journal of…