, 2022-12-10 23:57:44,
Altering the diet could be helpful in taking down colon cancer, reveals a new study conducted by researchers from University of Michigan Rogel Cancer Centre, reported by Science Daily.
Cancer cells, much like human cells, need nutrients to grow. And one most crucial nutrient-sensing molecule in a cell is dubbed mTORC1. Regarded as the master regulator of cell growth, it allows cells to sense different nutrients and help them grow and expand.
When the nutrients aren’t enough, cells reduce the intensity of looking for nutrients, turning off mTORC1 along the way.
Even though mTORC1 is regarded to be hyperactive in colon cancer, the biggest concern is whether colon tumours take control over nutrient-sensing pathways to force mTORC1 to go into overdrive.
Senior author Yatrik M. Shah, PhD, Horace W. Davenport Collegiate Professor of Physiology at Michigan Medicine explains that in the case of colon cancer, when the cells see there aren’t enough nutrients available, they go into a crisis state as they don’t really know what to do, resulting in massive cell death.
Researchers found in cells and in mice that a low-protein diet blocked the nutrient signalling pathway that started the master regulator (mTORC1) responsible for cancer growth.
mTORC1 is known to control how cells should use nutritional signals to grow and multiply. It’s seen to be very active in cancers with some mutations, and it can also become resistant to standard…
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