Why might males have a higher risk of heart problems?

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• A lack of adequate expansion of blood vessels in response to the accumulation of excess energy as fat plays a role in the development of obesity and metabolic disorders.
• Research shows that female mice tend to show greater levels of growth of blood vessels in adipose (fat) tissue, and better metabolic health than males in response to a high-fat diet.
• Endothelial cells form the inner lining of blood vessels and play a critical role in the growth of new blood vessels.
• A recent study found that endothelial cells from male adipose tissue showed greater expression of inflammation-related genes, but lower levels of cell proliferation genes than those from females in response to the accumulation of body fat.
• These results suggest that sex differences in adipose endothelial cell behavior could explain, in part, the greater risk of obesity-related complications in males.

Women show differences in the distribution and function of adipose tissue than men and are at a lower risk of obesity-related disorders.

A recent study also showed that female mice show greater levels of blood vessel growth in adipose tissue and maintain better metabolic health than males in response to the accumulation of body fat.

A new study published in iScience compared the differences in gene expression patterns of adipose tissue endothelial…